Unigan Drug Interactions

Certain hypnotics and anti-epileptics (e.g. Glutethimide. Phenobarbital, Phenytoin, Carbamazepine) as well as Rifampicin. The same applies to potentially hepatotoxic substances and alcohol abuse.
Long-term use of Paracetamol in patients being treated with oral anti-coagulants is only advisable under medical supervision.
Concomitant use of Paracetamol and Zidovudine [azidothymidine (AZT) or Retrovir] enhances the tendency towards reducing leukocytes (neutropenia). Therefore, UNIGAN should only be taken together with Zidovudine following medical advice.
The Paracetamol dose should be reduced during concurrent administration with Probenecid.
Cholestyramine reduces the absorption or Paracetamol.
The anticholinergic effect of drugs e.g. tri- and tetracyclic antidepressants, antihistamines. antipsychotics, Quinidine, Amantadine, Disopyramide and other anticholinergics (e.g. Tiotropium, Ipratropium, atropine-like compounds) may be intensified by UNIGAN.
Concomitant treatment with dopamine antagonists e.g. metoclopramide may result in diminution of the effects of both drugs on the gastrointestinal tract.
The tachycardic effects of β-adrenergic agents may be enhanced by UNIGAN.