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Amitriptyline, a dibenzocycloheptadiene, is usually given by mouth as the hydrochloride and doses are expressed in terms of this salt. Amitriptyline hydrochloride is also given by intramuscular or slow intravenous injection; doses may be expressed in terms of the base or the hydrochloride. Amitriptyline hydrochloride 75 mg is equivalent to about 66.3 mg of the base. Amitriptyline has also been given by mouth as the embonate and as the oxide (amitriptylinoxide).
Administration: 10 to 20 mg for children aged 6 to 10 years.
25 to 50 mg for children over 11 years of age.
The dose should be given 30 minutes before bedtime and treatment, including a period of gradual withdrawal, should not continue for longer than 3 months. A full physical examination is recommended before a further course. Or as prescribed by the physician.
