Topoccord 1/Topoccord 4 Caution For Usage

Special precautions for disposal and other handling: Topotecan is provided as a sterile concentrate containing 1 mg Topotecan in 1 ml solution and 4 mg Topotecan in 4 ml solution.
Parenteral products should be visually inspected for particulate matter and discoloration prior to administration. This medicinal product is a clear yellow colour solution. If visible particles are observed, the product should not be administered. Further dilution with either sodium chloride 9 mg/ml (0.9%) solution for injection or glucose 50 mg/ml (5%) solution for injection is required, to obtain a final concentration of between 25 and 50 micrograms/ml prior to administration to the patient.
The normal procedures for proper handling and disposal of anticancer medicinal products should be adopted, namely: Personnel should be trained to reconstitute the medicinal product.
Pregnant staff should be excluded from working with this medicinal product.
Personnel handling this medicinal product during reconstitution should wear protective clothing including mask, goggles and gloves.
All items for administration or cleaning, including gloves, should be placed in high-risk, waste disposal bags for high-temperature incineration.
Accidental contact with the skin or eyes should be treated immediately with copious amounts of water. If there is lasting irritation, a doctor should be consulted.
Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
Incompatibilities: In the absence of compatibility studies, this medicinal product must not be mixed with other medicinal products.