Ovarian & SCLC Initially 1.5 mg/m
2 daily by IV infusion over 30 min for 5 consecutive days w/ a 3-wk interval between courses. If severe neutropenia (neutrophil count <0.5 x 10
9/L) for ≥7 days, or associated w/ fever or infection, or fall in platelet count <25 x 10
9/L occurs, reduced by 0.25-1.25 mg/m
2 daily (or subsequently down to 1 mg/m
2 daily).
Cervical carcinoma Initially 0.75 mg/m
2 daily by IV infusion over 30 min on days 1, 2 & 3 followed by cisplatin 50 mg/m
2 daily by IV infusion on day 1 repeated every 21 days for 6 courses or until disease progression. If severe neutropenia (neutrophil count <0.5 x 10
9/L) for ≥7 days, or associated w/ fever or infection, or fall in platelet count <25 x 10
9/L occurs, reduced by 20% (to 0.6 mg/m
2 daily or subsequently down to 0.45 mg/m
2 daily). Standard oncology practice for the management of neutropenia is either to administer topotecan w/ other medications (eg, G-CSF) or to reduce dose to maintain neutrophil counts.
Patients w/ renal impairment (CrCl 20-39 mL/min) 0.75 mg/m
2 daily for 5 consecutive days.
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