Tolanz 5/Tolanz 10 Dosage/Direction for Use

Schizophrenia: The recommended starting dose is 10mg daily.
Acute Manic Episodes: A recommended initial dose is 10 to 15mg daily by mouth as monotherapy or 10mg if given as part of combination therapy; dosage adjustments of 5mg may subsequently be made at intervals of not less than 24 hours if necessary within the range 5 to 20mg daily. If a response is achieved, therapy may continue at the same dosage to prevent recurrence.
Prevention of Recurrence: In patients whose manic episodes have responded previously to olanzapine the recommended starting dose is 10 mg daily.
Patients with Hepatic and/or Renal Impairment: A starting dose of 5mg daily by mouth may be necessary for patients with renal impairment; for patients with moderate hepatic insufficiency the starting dose should be 5mg daily, and only increased with caution.
Others: The metabolism of Olanzapine might be slower in female, elderly, or non-smoking patients; if more than one of these factors is present, a lower initial dose (e.g. 5 mg daily if given by mouth) and a more gradual dose escalation should be considered.
Mode of Administration: Olanzapine orodispersible tablet should be placed in the mouth, where it will rapidly disperse in saliva, so it can be easily swallowed. Removal of the intact orodispersible tablet from the mouth is difficult. Since the orodispersible tablet is fragile, it should be taken immediately on opening the blister. Alternatively, it may be dispersed in a full glass of water or other suitable beverage (orange juice, apple juice, milk or coffee) immediately before administration.