Tolanz 5/Tolanz 10 Adverse Reactions

The most frequent adverse effects with Olanzapine are somnolence and weight gain; hyperprolactinemia is also common, but usually asymptomatic. Increased appetite, dizziness, elevated plasma glucose, triglyceride, and liver enzyme values, eosinophilia, edema, orthostatic hypotension, and mild transient antimuscarinic effects such as constipation and dry mouth are also relatively common. Speech difficulty has also been reported. More severe abnormalities of glucose homeostasis occur uncommonly; severe hyperglycemia, or exacerbation of pre-existing diabetes, sometimes leading to ketoacidosis or coma, has been reported. Clinical monitoring for hyperglycemia has been recommended, especially in patients with or at risk of developing diabetes. Olanzapine has been associated with a low incidence of extrapyramidal symptoms including tardive dyskinesia although extrapyramidal symptoms may be more likely at high doses. Neuroleptic malignant syndrome has been reported rarely.