Tigilyn Drug Interactions

Interaction studies have only been performed in adults.
Concomitant administration of Tigecycline (Tigilyn) and warfarin (25 mg single-dose) to healthy subjects resulted in a decrease in clearance of R-warfarin and S-warfarin by 40% and 23%, and an increase in AUC by 68% and 29%, respectively. The mechanism of this interaction is still not elucidated. Available data does not suggest that this interaction may result in significant INR changes. However, since Tigecycline (Tigilyn) may prolong both prothrombin time (PT) and activated partial thromboplastin time (aPTT), the relevant coagulation tests should be closely monitored when Tigecycline (Tigilyn) is co-administered with anticoagulants. Warfarin did not affect the pharmacokinetic profile of Tigecycline (Tigilyn).
Tigecycline (Tigilyn) is not extensively metabolised. Therefore, clearance of Tigecycline (Tigilyn) is not expected to be affected by active substances that inhibit or induce the activity of the CYP450 isoforms. In vitro, Tigecycline (Tigilyn) is neither a competitive inhibitor nor an irreversible inhibitor of CYP450 enzymes.
Tigecycline (Tigilyn) in recommended dosage did not affect the rate or extent of absorption, or clearance of digoxin (0.5 mg followed by 0.25 mg daily) when administered in healthy adults. Digoxin did not affect the pharmacokinetic profile of Tigecycline (Tigilyn). Therefore, no dosage adjustment is necessary when Tigecycline (Tigilyn) is administered with digoxin.
In in vitro studies, no antagonism has been observed between Tigecycline (Tigilyn) and other commonly used antibiotic classes.
Concurrent use of antibiotics with oral contraceptives may render oral contraceptives less effective.