Synalar HP: Topically applied corticosteroids can be absorbed in large amounts to produce systemic effects. Patients (particularly children) receiving a large dose of topical corticosteroid applied to a large surface area or under an occlusive dressing should be evaluated for evidence of Hypothalamus-Pituitary-Adrenal (HPA) axis suppression. This can be tested through Urinary free cortisol and ACTH Stimulation test. If HPA axis suppression is noted, the dose should be reduced or discontinue the drug or to substitute a less potent steroid.
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