Spiros Dosage/Direction for Use

Oedema: Initial dose of 100 mg daily by mouth, subsequently adjusted as necessary; some patients may require doses of up to 400 mg daily.
Hepatic cirrhosis with ascites and oedema: patients with a urinary sodium/potassium ratio greater than 1 may be given an initial dose of 100 mg daily; while patients with a ratio less than 1 may be given initial dose of 200 to 400 mg daily.
Hyperaldosteronism: 400 mg daily in the presumptive diagnosis of primary hyperaldosteronism; 100 to 400 mg daily for pre-operative management of hyperaldosteronism and in the lowest effective dosage for long term maintenance therapy in the absence of surgery.
Heart failure: In patients with severe heart failure, addition of spironolactone in a dose of 25 to 50 mg therapy with ACE Inhibitors and loop diuretics reduced the risk of death and hospitalization.
Hirsutism: 50 to 200 mg daily for idiopathic hirsutism or polycystic ovary syndrome preferably in combination with oral contraceptives.