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Spironolactone is contraindicated in the following: Patients with anuria (patients are at greater risk of developing hyperkalemia).
Acute renal insufficiency, severe or rapidly progressing impairment of renal function (spironolactone may aggravate electrolyte imbalance and the risk of developing hyperkalemia is increased).
Hyperkalemia (spironolactone may further increase serum potassium concentrations).
Patients who are hypersensitive to spironolactone or any of the ingredients in the product.
Addison's disease.
Diabetes mellitus, especially in patients with confirmed or suspected renal insufficiency.
Diabetic nephropathy (increased risk of hyperkalemia. Spironolactone should be discontinued at least 3 days prior to a glucose tolerance test because of the risk of hyperkalemia).
Breast-feeding is contraindicated.
