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Symptoms: Reported cases of somatostatin overdose did not reveal other safety hazard than the undesirable effects observed at recommended doses.
Treatment: Close monitoring of blood glucose level, cardiovascular parameters, renal function, and plasma electrolytes is recommended in case of somatostatin overdose.
After interruption of a somatostatin I.V. infusion given at therapeutic dose, the t1/2 of somatostatin in blood is about 2 min.
Treatment of overdose is symptomatic, no specific antidote is known.
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