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Taking into account the wide range of somatostatin pharmacodynamic effects on various regulating systems, there is a potential for many pharmacodynamic interactions.
Pharmacodynamic interactions with possible clinical relevance have been observed with drugs that also influence blood glucose regulation, plasma renin level and arterial blood pressure, showing that somatostatin may modify the effects of these drugs on these parameters.
Simultaneous administration of any form of sugar (including glucose and fructose solutions or total parenteral nutrition) favors glycemic disturbances and requires a closer monitoring of blood sugar. Administration of insulin may be required.
Incompatibilities: None known.
Somatostatin is compatible with glucose (5% and 10%) and fructose solutions (40%).
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