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The monitoring of the plasma levels of sulfadiazine is not necessary, except probably in patients with impaired hepatic or renal functions when the drug is applied to an extensive surface under occlusive bandage or to damaged skin especially in burn areas.
Should a massive absorption of the drug occur, its elimination through the urine must be enhanced with the ingestion of abundant bicarbonate liquid preparations. In the event of serious crystalluria, urethral catheterization may be necessary.
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