LINEZOLID formulations are contraindicated for use in patients who have known hypersensitivity to linezolid or any of the other product components.
Monoamine oxidase inhibitors: Linezolid should not be used in patients taking any medicinal product which inhibits monoamine oxidases A or B (e.g., phenelzine, isocarboxazid, selegiline, moclobemide) or within two weeks of taking any such medicinal product.
Unless patients are monitored for potential increases in blood pressure, since potential interactions producing elevation of blood pressure, linezolid should not be administered to the following patients: Patients with uncontrolled hypertension; Patients with pheochromocytoma; Patients with thyrotoxicosis; Patients with bipolar disorder; Patients with schizoaffective disorder; Patients with acute confusional state; Patients taking any of the following types of medications: directly and indirectly acting sympathomimetic agents (e.g., pseudoephedrine), vasopressive agents (e.g., epinephrine, norepinephrine), dopaminergic agents (e.g., dopamine, dobutamine).
Unless clinically appropriate and patients are clinically observed for signs and symptoms of serotonin syndrome or neuroleptic malignant syndrome like (NMS-like) reactions, linezolid should not be administered to patients with: Patients with carcinoid syndrome; Patients taking any of the following medications: serotonin re-uptake inhibitors, tricyclic antidepressants, serotonin 5HT1 receptor agonists (triptans), meperidine, bupropion, or buspirone.
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