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Precautions in Storage and Handling: Do not transfer the drug from the original package to other one. It may result in accidents and/or deteriorate the quality of drug.
Intravenous Administration: LINEZOLID is supplied in single-use, ready-to-use infusion bags. Parenteral drug products should be inspected visually for particulate matter prior to administration. Check for minute leaks by firmly squeezing the bag. If leaks are detected, discard the solution, as sterility may be impaired.
LINEZOLID should be administered by intravenous infusion over a period of 30 to 120 minutes. Do not use this intravenous infusion bag in series connections. Additives should not be introduced into this solution. If LINEZOLID I.V. Injection is to be given concomitantly with another drug, each drug should be given separately in accordance with the recommended dosage and route of administration for each product. In particular, physical incompatibilities resulted when LINEZOLID I.V. Injection was combined with the following drugs during simulated Y-site administration: amphotericin-B, chlorpromazine HCl, diazepam, pentamidine isethionate, erythromycin lactobionate, phenytoin sodium, and trimethoprim-sulfamethoxazole. Additionally, chemical incompatibility resulted when LINEZOLID I.V. injection was combined with ceftriaxone sodium.
If the same intravenous line is used for sequential infusion of several drugs, the line should be flushed before and after infusion of LINEZOLID I.V. Injection with an infusion solution compatible with LINEZOLID I.V. Injection and with other drug(s) administered via this common line (see Compatible Intravenous Solutions as follows).
Compatible Intravenous Solutions: 5% Dextrose Injection, 0.9% Sodium Chloride Injection, Lactated Ringer's Injection.
Keep the infusion bags in the overwrap until ready to use. Store at room temperature. Protect from freezing. LINEZOLID I.V. Injection may exhibit a yellow color that can intensify over time without adversely affecting potency.
How to Use Safe-Flex container: 1. By placing the bag upside down, hold the upper part of the safe-flex bag with your hand, and then hold the opening with the other hand and gently pull the over-wrap downward (horizontal direction from body) while you remove the over-wrap.
2. After checking the product's condition, if medication needs to be added to the bag, you can insert the 19-22 gauge needle into the medication port of your bag which is closed with a yellow rubber cap. Additional medication can be inserted about 5 to 6 times.
3. Rotate the blue protection cap and remove it.
4. Insert the spike of infusion set by turning to the right.
5. When you check the scale while the infusion, scale can be read at the front The error range is less than ±5%.
6. After the administration, collect the empty bag and dispose off property.
