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Pregnancy: There is no evidence of untoward effects in human pregnancy. In large doses, there is evidence of decreased pup survival in rats and an embryological effect in rabbits if bupivacaine is administered in pregnancy, Bupivacaine should not, therefore, be given in early pregnancy unless the benefits are considered to outweigh the risks.
Sergivell Plain: It should be noted that the dose should be reduced in patients in the late stages of pregnancy, see Precautions.
Sergivell Iso: Fetal adverse effects due to local anesthetics, such as fetal bradycardia (negative chronotropic effect of a local anesthetic on the myocardium of the fetus and vasoconstriction of uterine blood vessels) seem to be most apparent in paracervical block anesthesia. Such effects may be due to high concentrations of anesthetic reaching the fetus.
Lactation: Bupivacaine is excreted into the mother's milk but in such small quantifies that there is no risk of affecting the child at therapeutic dose levels.
