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Sergivell Plain: At the recommended use of the medicine, it is unlikely to reach toxic systemic concentrations of the active ingredient. However, when administered concurrently to other local anaesthetics there is a summation of toxic effects and systemic toxic reactions may occur (see Acute systemic toxicity and Treatment of acute systemic toxicity under Adverse Reactions).
Sergivell Iso: Accidental intravascular injections of local anesthetics may cause immediate (within seconds to a few minutes) systemic toxic reactions. In the event of an overdose, systemic toxicity appears later (15-60 minutes after injection) due to the slower increase in local anesthetic blood concentration.
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