Sertraline should be used with caution and in reduced doses in patients with renal impaired hepatic or renal function and some authorities recommend that they should not be used in severe hepatic or renal failure.
In patients taking electroconvulsive therapy, Sertraline administration should be avoided.
Concomitant use of Sertraline and MAO Inhibitors should be avoided; at least 14 days should be elapsed between discontinuation of MAOs and initiation of Sertraline.
Since antidepressants may impair the ability to perform potentially hazardous tasks (driving a vehicle or operating machinery) the patient should be warned accordingly. Sertraline should be avoided in patients with unstable epilepsy. In case of controlled epilepsy patients should be carefully monitored and Sertraline should be discontinued if patients develops seizures.
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