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The potentiating action of hydroxyzine must be considered when the drug in conjunction with central nervous system depressants such as narcotics, non-narcotic analgesics and barbiturates. Therefore when central nervous system depressants are administered concomitantly with hydroxyzine their dosage should be reduced.
Since drowsiness may occur with use of this drug, patients should be warned of this possibility and cautioned against driving a car or operating dangerous machinery while taking hydroxyzine. Patients should be advised against the simultaneous use of other CNS depressant drugs, and cautioned that the effect if alcohol may be increased.
