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The usual doses by mouth in adults are: 50 to 100 mg four times daily for the short-term management of anxiety; for pruritus an initial dose of 25 mg given at night, increased if necessary to 25 mg three or four time daily; and 50 to 100 mg for pre- or post-operative sedation. For pruritus in children over 6 years of age the initial dose is 15 to 25 mg daily increased to 50 to 100 mg daily in divided doses.
Administration in Hepatic or Renal Impairment: In patients with hepatic impairment, UK licensed product information recommends a 33% reduction in the total daily dose of hydroxyzine by mouth. In patients with moderate or severe renal impairment, a dose reduction of 50% is recommended.
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