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Metronidazole may impair the metabolism or excretion of warfarin, phenytoin, lithium, ciclosporin and fluorouracil. The metabolism of metronidazole might be accelerated by phenytoin. Phenobarbital decreases the plasma concentration of metronidazole. Cimetidine increases the plasma concentrations of metronidazole and might increase the risk of neurological adverse effects.
Alcohol when taken with metronidazole may provoke a disulfiram-like reaction in some patients. Acute psychoses or confusion have been reported.
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