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Metronidazole should not be given to patients with history of hypersensitivity to imidazoles.
Metronidazole should not be taken more than the recommended dosage and duration. In patients given metronidazole for more than 10 days, clinical and laboratory monitoring is advise. Blood test should be monitored regularly especially the leucocyte count.
Special warning for patients with active or chronic severe peripheral and central nervous system diseases. As metronidazole is metabolized in the liver, doses should be reduced in patients with severe hepatic impairment.
Patients should not drink alcoholic beverages while taking metronidazole.
Metronidazole has shown to be carcinogenic in mice and possibly in rats. Unnecessary use of the drug should therefore be avoided.
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