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Pregnancy: There are no or a limited amount of data from the use of Piperacillin/Tazobactam in pregnant women.
Studies in animals have shown developmental toxicity, but no evidence of teratogenicity, at doses that are maternally toxic.
Piperacillin and Tazobactam cross the placenta. Piperacillin/Tazobactam should only be used during pregnancy if clearly indicated i.e. only if the expected benefit outweighs the possible risks to the pregnant woman and fetus.
Breastfeeding: Piperacillin is excreted in low concentrations in human milk, Tazobactam concentrations in human milk have not been studied. Women who are breast-feeding should be treated only if the expected benefit outweighs the possible risks to the woman and child.
Fertility: A fertility study in rats showed no effect on fertility and mating after intraperitoneal administration of tazobactam or the combination Piperacillin/Tazobactam.
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