RiteMED Meropenem Trihydrate Dosage/Direction for Use

Meropenem is administered by intravenous (IV) bolus injection or IV infusion.
IV bolus injection (5 to 20 mL) is given over approximately 3 to 5 minutes.
There are limited safety data available to support the administration of a 2 g dose in adults or a 40 mg/kg body weight in children, as an IV bolus injection.
IV infusion is given over approximately 15 to 30 minutes.
Usual Adult Dose: 500 mg to 1 g IV every 8 hours, depending on the type and severity of infection, the known or suspected susceptibility of the pathogens and the condition of the patient.
Recommended Dose for Specific Infections in Adults: (See Table 3.)

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As with other antibiotics, caution may be required in using meropenem as monotherapy in critically ill patients with known or suspected Pseudomonas aeruginosa lower respiratory tract infections. When treating infections known or suspected to be caused by P. aeruginosa, a dose of at least 1 g three times a day in adults (maximum approved dose: 6 g/day given in 3 divided doses) is recommended. This dose is based on pharmacokinetic/pharmacodynamic modeling and probability of target attainment stimulation for susceptible strains of P. aeruginosa (MIC=2 mcg/mL).
Adults with Renal Impairment: The dose of meropenem should be reduced in patients with creatinine clearance less than 51 mL/min. (See Table 4.)

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Meropenem is removed by hemodialysis and hemofiltration; if continued treatment with meropenem is necessary, the dose, based on the type and severity of infection, should be administered at the completion of the hemodialysis procedure to reinstitute effective treatment.
There are no established dose recommendations for patients receiving peritoneal dialysis.
When only serum creatinine is available, the following formula may be used to estimate creatinine clearance in adults. Serum creatinine should represent a steady state of renal function: (See equation.)

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Usual Pediatric Dose: Children=3 months old up to 12 years old (weighing=50 kg): 10 to 40 mg/kg body weight every 8 hours, depending on the type and severity of infection, known or suspected susceptibility of the pathogens and condition of the patient (see table as follows.)
Recommended Dose for Specific Infections in Children: (See Table 5.)

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When treating infections known or suspected to be caused by P. aeruginosa, a dose of at least 20g/kg body weight three times a day in children (maximum approved dose: 120 mg/kg body weight/day given in three divided doses) is recommended.
Children >50 kg: Follow usual adult dosing.
Children with Renal Impairment: There are no data on appropriate doses for pediatric patients with renal impairment.
Usual Duration of Treatment: 7 to 14 days depending on the type and severity of infection.
Or, as prescribed by a physician.