RiteMED Clindamycin Overdosage

The minimal toxic or lethal dose of clindamycin is not well established. At therapeutic doses, the primary toxic effects may involve the GI tract and may include severe diarrhea and pseudomembranous colitis that may result in death. Dermatitis, nephrotoxicity, hepatotoxicity, and various hematological abnormalities may occur less frequently.
No specific antidote is known. Supportive management should be initiated during overdose since hemodialysis and peritoneal dialysis are not effective in removing clindamycin from the serum. Monitor full blood count and liver function tests in patients with significant exposure as clindamycin may produce abnormalities of the hematopoietic system, and may cause hepatotoxicity. Monitoring serum concentration in patients with markedly reduced renal and hepatic function may be useful during high-dose therapy.
In cases of serious allergic anaphylactoid reactions, immediate emergency treatment including epinephrine, oxygen and IV corticosteroids should be administered as indicated.