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Aminoglycosides: Monitor renal function carefully if high doses of aminoglycosides are to be administered with cefepime because of increased potential of nephrotoxicity and ototoxicity.
Diuretics: Nephrotoxicity has been reported following concomitant administration of other cephalosporins with potent diuretics such as furosemide.
Interference with Laboratory Tests: Cephalosporins can cause false-positive results in urine glucose determinations using cupric sulfate solution (Benedict's reagent, Clinitest). It is recommended to use glucose oxidase methods (e.g., Clinistix).
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