RiteMED Cefepime Dosage/Direction for Use

For IV or IM administration.
Dosage and route or administration should be determined by the severity of infection, susceptibility of the causative organisms and the patient's condition. The IV route is preferable patients with severe or life-threatening infections, particularly if the possibility of shock is present. (See Table 3.)

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Dose in Adults with Renal Impairment: Initial Dose: The same as in patients with normal renal function except in patients undergoing hemodialysis.
Adjust cefepime maintenance dose to compensate for the slower rate of renal elimination. (See Table 4.)

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When serum creatinine is available, the following formula may be used to estimate creatinine clearance in adults. Serum creatinine should represent a steady state of renal function: See equation as follows.

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Dose in Children with Renal impairment: Data is not available on dosing in children with renal impairment; however, reduction in dose and increase in dosing interval may follow the same recommendations for adults.
When only serum creatinine is available, creatinine clearance in children may be estimated using either of the following methods: See equation as follows.

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Or, as prescribed by a physician.