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Risperidone is contraindicated in patients with pre-existing CNS depression or coma, bone marrow suppression, pheochromocytoma, or
prolactin-dependent tumors. It should be used with caution or not at all in patients with impaired liver, kidney, cardiovascular, cerebrovascular and respiratory function and in those with angle-closure glaucoma, history of jaundice, parkinsonism, diabetes mellitus, hypothyroidism, myasthenia gravis, paralytic ileus, prostatic hyperplasia or urinary retention. Care is required in patients with epilepsy or history of seizures.
The sedative effects of risperidone are most marked during the first few days of administration; affected patients should not drive or operate machines.
Risperidone is generally not recommended late in pregnancy as such may be associated with intoxication of the neonates.
