Adults w/ established atherosclerotic CV disease (MI, stroke, or peripheral arterial disease) to reduce CV risk by lowering LDL-C levels, as an adjunct to correction of other risk factors in combination w/ the max tolerated dose of a statin w/ or w/o other lipid-lowering therapies or, alone or in combination w/ other lipid-lowering therapies in patients who are statin-intolerant, or for whom a statin is contraindicated. Adults w/ hyperlipidaemia, alone or in combination w/ other lipid-lowering therapies, as an adjunct to diet to reduce LDL-C. Ped patients ≥10 yr w/ heterozygous familial hypercholesterolaemia (HeFH) as an adjunct to diet, alone or in combination w/ other lipid-lowering therapy, to reduce LDL-C. Adult & ped patients ≥10 yr w/ HoFH in combination w/ other lipid-lowering therapies.
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