Renvex Dosage/Direction for Use

Starting Dose for Adult Patients Not Taking a Phosphate Binder: The recommended starting dose of sevelamer carbonate tablets is 0.8 to 1.6 g taken orally with meals based on serum phosphorus level. Table 1 provides recommended starting doses of sevelamer carbonate tablets for adult patients not taking a phosphate binder. See Table 3.

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Dose Titration for Adult Patients Taking Sevelamer Carbonate Tablets: Titrate the sevelamer carbonate tablets dose by 0.8 g three times per day with meals at two-week intervals as necessary to achieve target serum phosphorus levels. Based on clinical studies, the average prescribed adult daily dose of sevelamer carbonate is approximately 7.2 g per day. The highest daily adult dose of sevelamer carbonate studied was 14 grams in CKD patients on dialysis.
Starting Dose for Pediatric Patients Not Taking a Phosphate Binder: The recommended starting dose for pediatric patients 6 years of age and older is 0.8 g to 1.6 g taken three times per day with meals based on the patient's body surface area (BSA) category (see Table 4).

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Dose Titration for Pediatric Patients Taking Sevelamer Carbonate Tablets: Titrate the sevelamer carbonate tablets dose as needed to achieve target levels at two-week intervals based on BSA category, as shown in Table 4.
Switching from Sevelamer Hydrochloride Tablets: For adult patients switching from sevelamer hydrochloride tablets to sevelamer carbonate tablets or powder, use the same dose in grams.
Switching between Sevelamer Carbonate Tablets and Powder: Use the same dose in grams.
Switching from Calcium Acetate: Table 5 gives recommended starting doses of sevelamer carbonate tablets based on a patient's current calcium acetate dose. See Table 5.

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