Ranesan Dosage/Direction for Use

Adults: Unless otherwise prescribed, the following doses are recommended: Standard treatment of local fibrinolysis: 0.5 g (1 ampoule of 5 mL) to 1 g (2 ampoules of 5 mL) tranexamic acid by slow intravenous injection (= 1 mL/minute) two to three times daily.
Standard treatment of general fibrinolysis: 1 g (1 ampoule of 10 mL or 2 ampoules of 5 mL) tranexamic acid by slow intravenous injection (= 1 mL/minute) every 6 to 8 hours, equivalent to 15 mg/kg BW.
Renal impairment: In renal insufficiency leading to a risk of accumulation, the use of tranexamic acid is contra-indicated in patient with severe renal impairment (see Contraindications). For patient with mild to moderate renal impairment, the dosage of tranexamic acid should be reduced according to the serum creatinine level: See Table 1.

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Hepatic impairment: No dose adjustment is required in patient with hepatic impairment.
Paediatric Population: In children from 1 year, for current approved indications, the dosage is in the region of 20 mg/kg/day. However, data on efficacy, posology and safety for these indications are limited.
The efficacy, posology and safety of tranexamic acid in children undergoing cardiac surgery have not been fully established.
Elderly: No reduction in dosage is necessary unless there is evidence of renal failure.
Method of administration: The administration is strictly limited to slow intravenous injection.