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Hypersensitivity to the active substance or to any of the excipients.
Acute venous or arterial thrombosis.
Fibrinolytic conditions following consumption coagulopathy except in those with predominant activation of the fibrinolytic system with acute severe bleeding.
Severe renal impairment (risk of accumulation).
History of convulsions.
Intrathecal and intraventricular injection, intracerebral application (risk of cerebral oedema and convulsions).
