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Symptomatic response to rabeprazole does not preclude the presence of gastric malignancy. Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with benzimidazoles to which group rabeprazole also belongs.
Rabeprazole, like other proton pump inhibitors, has potential to cause gastric carcinoids but the studies have not been conclusive. Rabeprazole Sodium + Itopride Hydrochloride capsules must not be opened, chewed or crushed; they should be swallowed as whole.
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