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Rabeprazole: There has been no experience with large overdoses with Rabeprazole. The maximum reported overdose was 80 mg. There were no clinical signs or symptoms associated with any reported overdose. Patients with Zollinger-Ellison syndrome have been treated with up to 120 mg rabeprazole QD. No specific antidote for rabeprazole is known. Rabeprazole is extensively protein bound and is not readily dialyzable. In the event of overdosage, treatment should be symptomatic and supportive.
Itopride: There have as yet been no reports of overdose in humans. The oral single dose LD 50 was >2000 mg/kg in mice and rats and about 600 mg/kg in dogs. In case of excessive overdosage the usual measures of gastric lavage and symptomatic therapy should be applied. Itopride does not cause QT prolongation.
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