Qursocare Drug Interactions

Cholestyramine, charcoal and antacids may reduce effectiveness.
Aluminum-based antacids may reduce absorption. Oestrogens and clofibrate may counteract effectiveness of ursodeoxycholic acid by increasing cholesterol elimination in bile. Possible increase in ciclosporin serum concentration. Decreased effectiveness of dapsone. Possible decrease in serum ciprofloxacin and nitrendipine.
Film-Coated Tablet: Ursodeoxycholic acid has been shown to reduce peak plasma concentrations (C_max) and area under the curve (AUC) of the calcium antagonist nitrendipine. An interaction with a reduction of the therapeutic effects of dapsone was also reported. These observations, together with in vitro findings could indicate a potential for ursodeoxycholic acid to induce cytochrome P450 (CYP450) 3A enzymes. Controlled clinical studies have shown, however, that ursodeoxycholic acid does not have a relevant inductive effect on CYP450 3A enzymes. Estrogenic hormones and blood cholesterol-lowering agents eg, clofibrate may increase biliary lithiasis, which is a counter-effect to ursodeoxycholic acid used for dissolution of gallstones.