Do not use if the gallbladder cannot be visualized on x-ray images or in cases of calcified gallstones, impaired contractility of the gallbladder or frequent episodes of biliary colic. Monitor liver function parameters [eg, AST (SGOT), ALT (SGPT) & γ-GT] every 4 wk during the 1st 3 mth of treatment, & thereafter every 3 mth. Visualize gallbladder (oral cholecystography) w/ overview & occlusion views in standing & supine positions (ultrasound control) 6-10 mth after beginning treatment. Reduce dose if diarrhea occurs & discontinue use in cases of persistent diarrhea. Treat women of childbearing potential only if they are on reliable contraception. Not to be taken during lactation.
Effectiveness may be reduced w/ cholestyramine, charcoal & antacids. Absorption may be reduced w/ Al-based antacids. Effectiveness may be counteracted by oestrogens & clofibrate. Possible increased serum conc of ciclosporin. Decreased effectiveness of dapsone. Possible decreased serum ciprofloxacin & nitrendipine.
Sign Out
