The most likely manifestation of overdosage would be hypotension and tachycardia; bradycardia could occur from parasympathetic (vagal) stimulation. Electrolyte depletion and dehydration occurs with overdose of Hydrochlorothiazide. In the event of overdosage, symptomatic and supportive measures should be employed. Neither Losartan nor its active metabolite can be removed from hemodialysis.