Pharmacology: Pharmacokinetics: Bioavailability of Losartan potassium is about 33% and is not altered by presence of food. About 14% of administered drug is metabolized into E-3174 in most cases. T-max for the drug is 1 hour and 3-4 hours for its metabolite. Terminal of the half-life of the drug could be 4 hours to 6 hours depending upon the population type. Losartan Potassium is converted in the liver, to its active metabolite E-3174, which is more potent antagonist of the At1 receptor. E-3174 is responsible for the most pharmacological effects of Losartan Potassium. Its half-life contributes to the extended duration of action of the drug. 30% of patients with severe hypertension get their conditions managed with Losartan Potassium plus Hydrochlorothiazide 12.5 mg in 12 weeks period. Clinical studies show that compared to Losartan potassium monotherapy the combination therapy is found to reduce diastolic BP additionally by 4 to 6 months of Hg in patients.
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