Pred 1/5/10/20/30/50

Endocrine, rheumatic & collagen disorders, dermatologic, ophth, resp & neoplastic diseases; allergic & edematous states.

5-25 mg daily, max of 60 mg daily in divided doses.

Should be taken with food: Take immediately after meals.

Hypersensitivity to glucocorticoids. Gastric & duodenal ulcers, systemic fungal infections, certain viral infections, glaucoma, live vaccines, & psychoses or severe psychoneuroses.

Pregnancy & lactation.

Fluid & electrolyte disturbances, psychiatric disturbances, Cushingoid state, hirsutism, visual disturbances, growth retardation, skin atrophy, facial erythema, aseptic osteonecrosis, amenorrhea.

Effect of glycosides can be enhanced by K deficiency. Enhanced K excretion w/ saluretics/laxatives. Reduced blood sugar-lowering effect of antidiabetic agents. Reduced or enhanced efficacy of coumarin anticoagulants. Increased risk of GI haemorrhages w/ non-steroidal antiphlogistic/antirheumatic agents, salicylates & indomethacin. Prolonged muscle relaxation effect of non-depolarising muscle relaxants. Additional increases in IOP w/ atropine & other anticholinergics. May lower blood conc of praziquantel. Increased risk of myopathies, cardiomyopathies w/ chloroquine, hydroxycloroquine, mefloquine. Reduced efficacy of somatropin. Enhanced efficacy w/ estrogens (eg, OCs). Possible inhibition of metabolism w/ liquorice. Reduced efficacy w/ rifampicin, phenytoin, barbiturates, bupropion, primidone. Increased blood levels of cyclosporine; increased risk of seizures w/ cyclosporine. Increased risk of hypokalaemia w/ amphotericin B. Enhanced effects of cyclophosphamide. Increased risk of occurrence of blood count changes w/ ACE inhibitors. Increased risk of systemic side effects w/ CYP3A inhibitors. Reduced absorption w/ Al & Mg antacids.

Corticosteroid Hormones

H02AB07 - prednisone ; Belongs to the class of glucocorticoids. Used in systemic corticosteroid preparations.

Rx