Precedex Caution For Usage

Preparation of Solution: Strict aseptic technique must always be maintained during handling of Dexmedetomidine.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
Do not use if product is discolored or if precipitate matter is present.
Dexmedetomidine (Precedex) Concentrate for Intravenous Infusion: Dexmedetomidine (Precedex) must be diluted with 0.9% sodium chloride injection to achieve required concentration (4 mcg/mL) prior to administration. Preparation of solutions is the same, whether for the loading dose or maintenance infusion.
To prepare the infusion, withdraw 2 mL of Dexmedetomidine (Precedex) Concentrate for Intravenous Infusion, and add to 48 mL of 0.9% sodium chloride injection to a total of 50 mL. Shake gently to mix well.
Administration with Other Fluids: Dexmedetomidine (Precedex) infusion should not be co-administered through the same intravenous catheter with blood or plasma because physical compatibility has not been established.
Dexmedetomidine (Precedex) has been shown to be incompatible when administered with the following drugs: amphotericin B, diazepam.
Dexmedetomidine (Precedex) has been shown to be compatible when administered with the following intravenous fluids: 0.9% sodium chloride in water; 5% dextrose in water; 20% mannitol; Lactated Ringer's solution; 100 mg/mL magnesium sulfate solution; 0.3% potassium chloride solution.
Compatibility with Natural Rubber: Compatibility studies have demonstrated the potential for absorption of Dexmedetomidine (Precedex) to some types of natural rubber. Although Dexmedetomidine (Precedex) is dosed to effect, it is advisable to use administration components made with synthetic or coated natural rubber gaskets.