Prazitam-2.25/Prazitam-4.5 Dosage/Direction for Use

Piperacillin/Tazobactam (Prazitam-2.25/Prazitam-4.5) should be administered by intravenous infusion over 30 minutes.
Adults: The usual total daily dose of Piperacillin/Tazobactam is 3.375 g every six hours totaling 13.5 g (12.0 g Piperacillin/1.5 g Tazobactam).
Initial presumptive treatment of patients with nosocomial pneumonia should start with (16.0 g Piperacillin/2.0 g Tazobactam). Treatment with aminoglycoside should be continued in patients from whom Pseudomonas aeruginosa is isolated. If Pseudomonas aeruginosa is not isolated, the aminoglycoside may be discontinued at the discretion of the treating physician.
Pediatrics: Piperacillin/Tazobactam (Prazitam-2.25/Prazitam-4.5) can be administered in pediatric patients from 2 months of age. The dosage and indications in pediatric patients with normal renal function are as follows: See Table 1.

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Duration Of Therapy: The usual duration of Piperacillin/Tazobactam treatment is from seven to ten days. However, the recommended duration of treatment of nosocomial pneumonia is 7 to 14 days. In all conditions, the duration of therapy should be guided by the severity of the infection and the patient's clinical and bacteriological progress.
Renal Insufficiency: In patients with renal insufficiency (creatinine clearance < mL/min), the intravenous dose of Piperacillin/Tazobactam should be adjusted to the degree of actual renal function impairment. In patients with nosocomial pneumonia receiving concomitant aminoglycoside therapy, the aminoglycoside dosage should be adjusted according to the recommendation of the manufacturer.
Adults: See Table 2.

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For patients on hemodialysis, the maximum dose is 2.25 g every twelve hours for all indications other than nosocomial pneumonia and 2.25 g every eight hours for nosocomial pneumonia. Since hemodialysis removes 30% to 40% of the administered dose, an additional dose of 0.75 g Piperacillin/Tazobactam should be administered following each dialysis period on hemodialysis days. No additional dosage of Piperacillin + Tazobactam is necessary for CAPD patients.
Pediatrics: There are no dosage recommendation for Piperacillin/Tazobactam in pediatric patients with impaired renal function.