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Pioglitazone is indicated in the treatment of type 2 diabetes mellitus: As monotherapy: In patients (particularly overweight patients) inadequately controlled by diet and exercise for whom metformin is inappropriate because of contraindications or intolerance.
As dual oral therapy in combination with: Metformin, in patients (particularly overweight patients) with insufficient glycemic control despite maximal tolerated dose of monotherapy with metformin.
A sulphonylurea, only in patients who show intolerance to metformin or for whom metformin is contraindicated, with insufficient glycemic control despite maximal tolerated dose of monotherapy with a sulphonylurea.
As triple oral therapy in combination with: Metformin and a sulphonylurea, in patients (particularly overweight patients) with insufficient glycemic control despite dual oral therapy.
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