PPAR Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing Brand Resources

Concise Prescribing Info

Contents

Pioglitazone HCl

Indications/Uses

Type 2 DM: As monotherapy in patients inadequately controlled by diet & exercise for whom metformin is inappropriate because of contraindications or intolerance. As dual therapy in combination w/ metformin in patients w/ insufficient glycemic control despite maximal tolerated dose of monotherapy w/ metformin. As triple oral therapy in combination w/ metformin & sulphonylurea in patients w/ insufficient glycemic control despite dual oral therapy.

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Dosage/Direction for Use

Initially 15-30 mg once daily increased to 45 mg once daily according to response. May be increased in increments up to 45 mg once daily.

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Overdosage

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Administration

May be taken with or without food.

Contraindications

Hypersensitivity. Active or history of cardiac failure (NYHA stages I-IV). Hepatic impairment. Pregnancy & lactation.

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Warnings

For additional cautionary notes to warn of the potential risk of using the medicine... Click to view PPAR detailed prescribing information

Special Precautions

Not to be used in patients w/ active or history of heart failure & bladder cancer. Not indicated to patient w/ NYHA class III or IV cardiac status. Fluid retention may develop & risk of hypoglycemia. Patients w/ edema. Dose-related wt gain & resumption of ovulation may occur. Decreased Hb & hematocrit. Discontinue if any deterioration in cardiac status or jaundice occurs. Liver dysfunction.

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Use In Pregnancy & Lactation

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Adverse Reactions

GI disturbances, wt gain, edema, anemia, headache, visual disturbances, dizziness, arthralgia, hypoesthesia, hematuria, upper resp tract infection, sinusitis.

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Drug Interactions

Increased AUC w/ CYP2C8 inhibitor eg, gemfibrozil. Decreased AUC w/ CYP2C8 inducer eg, rifampin. Inhibits metabolism w/ ketoconazole.

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Storage

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Description

View PPAR description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Antidiabetic Agents

ATC Classification

A10BG03 - pioglitazone ; Belongs to the class of thiazolidinediones. Used in the treatment of diabetes.

Regulatory Classification

Presentation/Packing

Form

PPAR tab 30 mg

Packing/Price

30's

PPAR

pioglitazone

Manufacturer:

Medley Pharma

Distributor:

Bell-Kenz Pharma

Marketer:

Ambica