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Preparation: Intramuscular use: To prepare initial dilution for intramuscular use, add 0.9 to 1.9 mL of Sterile Water for Injection or Bacteriostatic Water for Injection to each 250 mg vial and 1.2 to 1.8 mL of diluent to each 500 mg vial and 1.5 mL of diluent to each 1 g vial.
Intravenous use: To prepare initial dilution for direct intermittent intravenous use, add 5 mL of Sterile Water for Injection or Bacteriostatic Water for Injection to each 250 mg or 500 mg vial and 1 g vial. The resulting solution should be administered slowly over a 3 to 5 min. period. More rapid administration may result in convulsive seizures.
For Administration by IV Drip: Reconstitute as directed previously (For Intravenous use) prior to diluting with IV Solution. Ampicillin is stable with commonly used intravenous fluids at 23°C if infused over a period of 6 hours. Solutions should be changed after 1 hour if Ampicillin is administered in fluids containing dextrose or other carbohydrates. Ampicillin should not be mixed with blood products or proteinaceous fluids such as protein hydrolysates nor with lipid emulsions. The drug concentration and the rate and volume of the infusion should be adjusted so that the total dose of ampicillin is administered before the drug loses its stability in use.
Directions for use: After reconstitution for intramuscular or direct intravenous use, solutions retain their potency for 1 hour. Use freshly prepared solutions only. Administer intramuscularly or intravenously within 1 hour after preparation since the potency may decrease significantly after this period.
