Ceftriaxone is a third-generation cephalosporin antibiotic used similarly to cefotaxime for the treatment of susceptible infections. They include chancroid, endocarditis, gastro-enteritis (invasive salmonellosis; shigellosis), gonorrhea, Lyme disease, meningitis (including meningococcal meningitis prophylaxis), septicemia, surgical infection (prophylaxis), syphilis, typhoid fever and Whipple's disease.