Pharmacort Overdosage

As the clinically effective dose of corticosteroids vary according to the infections and requirements of individual patient, it is difficult to define "excessive" dosage of corticosteroids. Reports of acute toxicity and/or death resulting from corticosteroids overdosage are rare. However, continued use of large doses of corticosteroids (which are often necessary to elicit a clinical response) without proper dose reduction, leads to exaggeration of usual corticosteroid-related problems and aggravate pre-existing disease states (i.e., ulcerations of the gastrointestinal tract, electrolyte disturbances, infections, diabetes, and edema).
Cushingoid state results after doses (daily or several times per week) over a protracted period. The dose of hydrocortisone should be gradually reduced over a period of time to minimized the risk of developing adrenal insufficiency.
There is no known specific antidote available. Treatment of acute overdose is symptomatic and supportive (including respiratory and cardiovascular function). In case of chronic toxicity, closely monitor fluids and electrolytes levels, serum levels are not clinically useful.
Hydrocortisone is dialyzable.