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Preparation and administration precautions: Care should be exercised in handling and preparation of pemetrexed infusion solutions. The use of gloves is recommended. If a pemetrexed solution contacts the skin, wash the skin immediately and thoroughly with soap and water. If pemetrexed solutions contact the mucous membranes, flush thoroughly with water. Pemetrexed is not a vesicant. There is not a specific antidote for extravasation of pemetrexed. There have been few reported cases of pemetrexed extravasation, which were not assessed as serious by the investigator. Extravasation should be managed by local standard practice as with other non-vesicants.
Direction for reconstitution: Reconstitute 500 mg vial with 20 mL Sodium Chloride Injection USP. Gently swirl each vial until the powder is completely dissolved.
Reconstituted solution contains 20 mL of 0.9% Sodium Chloride Injection USP (preservative free) into the vial to get a concentrate of 25 mg/mL of Pemetrexed.
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