Pemeta-100/Pemeta-500 Adverse Reactions

Pemetrexed may also cause fatigue, stomatitis, pharyngitis, dyspnoea, chest pain, and neuropathy. Rare cases of hepatitis, colitis, and intestinal pneumonitis have occurred; fatalities have been reported. Serious renal events, including acute renal failure, have been reported with pemetrexed when it was used either alone or with other cytotoxic drugs; most patients had underlying risk factors such as dehydration, hypertension, or diabetes. Cardiovascular events, including myocardial infarction and cerebrovascular events, have occurred rarely, when pemetrexed was used with other cytotoxic drugs. Cases of radiation pneumonitis and radiation recall have been reported in patients treated with radiotherapy. Hypersensitivity reactions may occur.
Complete blood cell counts should be monitored, and folate and vitamin B12 are given as prophylaxis against haematological and gastrointestinal toxicity during pemetrexed therapy. Pre-treatment with a corticosteroid, such as oral dexamethasone, reduces the incidence and severity of skin reactions.