Peldacyn Warnings

Solution for Injection: Clindamycin may be associated with severe colitis which may end fatally. Therefore, it should be reserved for serious infections where other antimicrobial agents are inappropriate.
It should not be used in patients with nonbacterial upper respiratory or mild bacterial infections. The colitis is usually characterized by severe, persistent diarrhea and severe abdominal pain and may be associated with the passage of blood and mucus. Endoscopic examination may reveal pseudomembranous colitis. When significant diarrhea occurs, the drug should be discontinued or, if necessary, continued only with close observation of the patient. Large bowel endoscopy has been recommended. Diarrhea, colitis and pseudomembranous colitis has been observed after several weeks following cessation of therapy with clindamycin.
Peldacyn should not be used in the treatment of meningitis, since it does not penetrate into the cerebrospinal fluid.
Clindamycin should not be used in the treatment of nonbacterial upper respiratory tract infection or patients with mild bacterial infections.