Peldacyn Caution For Usage

Capsule: Incompatibilities: Not applicable.
Solution for Injection: Dilution and Infusion Rates: Clindamycin phosphate must be diluted prior to IV administration. The concentration of clindamycin in diluent for infusion should not exceed 18 mg/mL, infusion rates should not exceed 30 mg/min. The usual infusion dilutions and rates are shown in Table 5. (See Table 5.)

Click on icon to see table/diagram/image

Dilution and Compatibility: Physical and biological compatibility studies for 24 hrs at room temperature have demonstrated no activation or incompatibility with use of clindamycin phosphate in IV solutions containing sodium chloride, glucose, calcium, potassium and solutions containing vitamin B complex in concentrations usually used clinically. No incompatibility has been demonstrated with the antibiotics cephalothin, kanamycin, gentamycin, penicillin or carbenicillin.
The following drugs are physically incompatible with clindamycin phosphate: Ampicillin, phenytoin, barbiturates, aminophylline, calcium gluconates and magnesium sulfate.
Precautions during application: After solution, it should be used as soon as possible. Store at room temperature and should be used within 48 hrs.
Pain and hardness at injection site may occur.
It should not be injected direct-IV because cardiac arrest may occur after directly rapid IV administration.